Cyclic strain disrupts endothelial network formation on Matrigel
نویسندگان
چکیده
منابع مشابه
Cyclic strain disrupts endothelial network formation on Matrigel.
Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to determine whether a range of mechanical stimuli exists in which angiogenesis is fa...
متن کاملProlonged cyclic strain inhibits human endothelial cell growth.
The vascular endothelium is continuously exposed to cyclic mechanical strain due to the periodic change in vessel diameter as a result of pulsatile blood flow. Since emerging evidence indicates the cyclic strain plays an integral role in regulating endothelial cell function, the present study determined whether application of a physiologic regimen of cyclic strain (6% at 1 hertz) influences the...
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Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...
متن کاملA Strain Range Dependent Cyclic Plasticity Model
Hysteresis loop curves are highly important for numerical simulations of materials deformation under cyclic loadings. The models mainly take account of only the tensile half of the stabilized cycle in hysteresis loop for identification of the constants which don’t vary with accumulation of plastic strain and strain range of the hysteresis loop. This approach may be quite erroneous particularly ...
متن کاملCyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity.
OBJECTIVE The purpose of this study was to determine the effect of cyclic strain on Notch signaling in endothelial cells. METHODS AND RESULTS Exposure of human endothelial cells (ECs) to cyclic strain (10%) resulted in temporal upregulation of Notch receptors (1 and 4) at the mRNA and protein level. Cyclic strain significantly increased EC network formation on Matrigel (an index of angiogenes...
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ژورنال
عنوان ژورنال: Microvascular Research
سال: 2009
ISSN: 0026-2862
DOI: 10.1016/j.mvr.2009.08.002